Sucralfate is used for the treatment of peptic ulcer disease and to prevent recurrent ulcers after healing of the ulcer has been achieved. It also has been used to relieve or prevent the ulcers caused by nonsteroidal anti-inflammatory drugs (NSAIDs) but is less effective than misoprostol (Cytotec). Sucralfate also is used in the treatment of patients with gastroesophageal reflux disease (GERD) who are prone to get ulcers in the esophagus, and to prevent ulcers associated with high degrees of physical stress (e.g. extensive burns, surgery, and overwhelming infection.) among hospitalized patients.